Glycine Transport Inhibitors for the Treatment of Pain

用于治疗疼痛的甘氨酸转运抑制剂

• 批准号: nhmrc : 1144429
• 负责人: A/Pr Renae Ryan
• 金额: $ 62.45万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/glycine-transport-inhibitors-treatment-pain/1320193
• 关键词: Glycine; Transport; Inhibitors; Treatment; Pain

Chronic pain is particularly difficult to treat. Whilst currently used opioid drugs are effective in acute pain, they are either ineffective in chronic pain or have considerable side effects. In this project we will develop a new class of analgesics that have a different mechanism of action to traditional analgesics. It is hoped that these new drugs will provide long term pain relief without debilitating side effects.

慢性疼痛尤其难以治疗。虽然目前使用的阿片类药物对急性疼痛有效，但它们对慢性疼痛无效或有相当大的副作用。在这个项目中，我们将开发一种新的镇痛药，具有不同于传统镇痛药的作用机制。人们希望这些新药能够长期缓解疼痛，而不会产生使人衰弱的副作用。