The structural basis for glutamate transporter function

谷氨酸转运蛋白功能的结构基础

• 批准号: nhmrc : 1048784
• 负责人: A/Pr Renae Ryan
• 金额: $ 24.88万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-basis-glutamate-transporter-function/112037
• 关键词: structural; basis; glutamate; transporter; function

Glutamate transporters are vacuum cleaners in the brain that suck the neurotransmitter glutamate into cells. When the glutamate vacuum breaks down or becomes blocked, glutamate levels outside cells increase, leading to cell death in the brain. This process underlies the damage in many brain diseases including Alzheimer’s disease and stroke. The aim of this project is to understand the mechanism of the glutamate vacuum cleaner so we can develop therapeutics to fix it when it breaks down.

谷氨酸转运蛋白是大脑中的吸尘器，将神经递质谷氨酸吸入细胞中。当谷氨酸真空破坏或被堵塞时，细胞外的谷氨酸水平就会增加，导致大脑中的细胞死亡。这一过程是许多脑部疾病（包括阿尔茨海默病和中风）损伤的基础。该项目的目的是了解谷氨酸真空吸尘器的机制，以便我们可以开发治疗方法来修复它。