Molecular Dynamics of Glutamate Transporters

谷氨酸转运蛋白的分子动力学

• 批准号: nhmrc : 457467
• 负责人: A/Pr Renae Ryan
• 金额: $ 32.84万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-dynamics-glutamate-transporters/96396
• 关键词: Molecular; Dynamics; Glutamate; Transporters

Neurotransmitter transporters are very good drug targets because modulation of their activity can lead to up and down regulation of neurotransmitter concentrations and thereby influence signalling pathways in the brain. This can be very useful in treating various neurological disorders and also altering normal brain functions such as learning and memory. In this project we will develop a detailed understanding of how glutamate transporters work and in so doing will be in a better position to design subtype and transporter-specific compounds. These compounds will be very useful in defining the role of glutamate transporter subtypes in normal and pathological states and may be useful in treating neurological disorders such as Alzheimer's disease, schizophrenia, ishaemia following a stroke, and motor neurone disease.

神经递质转运蛋白是非常好的药物靶点，因为它们活性的调节可以导致神经递质浓度的上调和下调，从而影响大脑中的信号通路。这在治疗各种神经系统疾病和改变正常的大脑功能（如学习和记忆）方面非常有用。在这个项目中，我们将详细了解谷氨酸转运蛋白是如何工作的，这样做将更好地设计亚型和转运蛋白特异性化合物。这些化合物在确定谷氨酸转运蛋白亚型在正常和病理状态中的作用方面将是非常有用的，并且可以用于治疗神经障碍，例如阿尔茨海默病、精神分裂症、中风后的缺血和运动神经元疾病。