The predictors of prostate cancer in the Melbourne Collaborative Cohort Study

墨尔本合作队列研究中前列腺癌的预测因素

• 批准号: nhmrc : 126402
• 负责人: Prof Graham Giles
• 金额: $ 23.9万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/predictors-prostate-cancer-cohort-study/99617
• 关键词: predictors; prostate; cancer; Melbourne; Collaborative

In 1990 we set up a long-term study of diet and health. The aim was to measure diet and other risk factors in healthy people in order to see how they might affect future development of cancer. To do this we recruited 41,500 people aged 40 to 69, measured what they ate and drank, and collected information on other aspects of lifestyle, medical history, and family history of common diseases. All had height and weight and blood pressure measured and gave a blood sample. People were selected so that men and women and migrants from Italy and Greece would be included. In this way we could widen the range of dietary habits, other lifestyle factors and genetic variation (measured in DNA from blood). Since then participants have completed another questionnaire and instances of disease have been noted from self reports and from examining medical records. We want to analyse data from 700 men in the study who have developed prostate cancer (PC). First we will analyse data collected on all 17,000 men (collected when joining the study, and at follow up). Next we will use data from only the 700 men with PC and 1400 men who have not developed PC. This study will focus on measuring substances in the blood. We want to measure a range of fats, vitamins, antioxidants and phytoestrogens, as well as male sex hormones and related substances. In the DNA from the blood we plan to measure variations in genes that influence how male sex hormones and other growth factors important in the prostate are produced and used. We will then be able to estimate what affect these factors have on the risk of getting PC. We will also be able to see if any of them act together to make the risk of PC much higher in certain men. This work should identify what lifestyle factors could reduce the risk of PC. It should also identify what genetic variations are associated with increased risk of PC and thus identify a sub group of men who might benefit from early medical attention or from changes in lifestyle.

1990年，我们设立了饮食与健康的长期研究。目的是测量健康人的饮食和其他危险因素，以了解它们如何影响癌症的未来发展。为此，我们招募了 41,500 名年龄在 40 至 69 岁之间的人，测量了他们的饮食情况，并收集了生活方式、病史和常见疾病家族史等其他方面的信息。所有人都测量了身高、体重和血压，并提供了血样。经过挑选的人员包括来自意大利和希腊的男性、女性以及移民。通过这种方式，我们可以扩大饮食习惯、其他生活方式因素和遗传变异（通过血液 DNA 测量）的范围。从那时起，参与者完成了另一份调查问卷，并从自我报告和检查医疗记录中记录了疾病实例。我们想要分析研究中 700 名患有前列腺癌 (PC) 的男性的数据。首先，我们将分析所有 17,000 名男性收集的数据（在加入研究时和随访时收集）。接下来，我们将仅使用 700 名拥有 PC 的男性和 1400 名尚未发展 PC 的男性的数据。这项研究将重点测量血液中的物质。我们想要测量一系列脂肪、维生素、抗氧化剂和植物雌激素，以及男性性激素和相关物质。我们计划在血液 DNA 中测量影响男性性激素和前列腺中重要的其他生长因子如何产生和使用的基因变异。然后我们将能够估计这些因素对患 PC 风险的影响。我们还将了解它们中的任何一个共同作用是否会导致某些男性患 PC 的风险更高。这项工作应确定哪些生活方式因素可以降低 PC 风险。它还应该确定哪些遗传变异与 PC 风险增加相关，从而确定可能受益于早期医疗护理或生活方式改变的男性亚组。