Brain-wide mapping of sensory perception and integration in a vertebrate model

脊椎动物模型中感官知觉和整合的全脑图谱

• 批准号: nhmrc : GNT1165173
• 金额: $ 59.32万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/brain-wide-mapping-vertebrate-model/1379389
• 关键词: Brain; wide; mapping; sensory; perception

Patients with psychiatric disorders often perceive sensory events abnormally, and the studies that are possible in humans and rodents have difficulty addressing why. Our project will develop a system in zebrafish for observing activity throughout the brain while we can still see each brain cell individually. This will allow us to see just how the brain encodes visual and auditory information, and how this activity changes when animals have mutations like those in human patients.

患有精神疾病的患者通常对感觉事件的感知异常，而在人类和啮齿动物身上可能进行的研究很难解释其中的原因。我们的项目将在斑马鱼身上开发一个系统，在我们还能单独看到每个脑细胞的时候，观察整个大脑的活动。这将使我们看到大脑是如何编码视觉和听觉信息的，以及当动物发生像人类患者那样的突变时，这种活动是如何变化的。