Importance of The Brain Renin-Angiotensin System For Regulating Blood Pressure and Cardiovascular Autonomic Function.

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The peptide angiotensin a major regulator of many brain areas controlling blood volume and blood pressure. Brain angiotensin may well contribute to high blood pressure but how it acts in each of the different brain areas is unknown. New gene transfer technology using viruses combined with genetically modified mice will enable this project to inactivate or activate angiotensin in each brain nucleus and determine the role of individual areas to setting of blood pressure leading to hypertension.