Neurogenic hypertension in the spontaneously hypertensive mouse : Role of the hypothalamic-brainstem sympathetic axis

自发性高血压小鼠的神经源性高血压：下丘脑-脑干交感轴的作用

• 批准号: nhmrc : 526662
• 负责人: Dr Pamela Davern
• 金额: $ 31.73万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/neurogenic-hypertension-spontaneously-sympathetic-axis/100287
• 关键词: Neurogenic; hypertension; spontaneously; hypertensive; mouse

In human high blood pressure, particularly in the young, an overactive nervous system is thought to be a major underlying cause. Using a unique mouse model of high blood pressure which closely resembles this aspect of the human disease, we will examine which brain cells and neuro- chemicals are involved, particularly in a small area that is involved in regulating the hormonal and nervous system response to stress. From this we hope to be able to target these chemicals with specific therapy.

在人类高血压中，特别是在年轻人中，过度活跃的神经系统被认为是一个主要的潜在原因。使用一个独特的高血压小鼠模型，它非常类似于人类疾病的这一方面，我们将研究哪些脑细胞和神经化学物质参与，特别是在一个小区域，参与调节激素和神经系统对压力的反应。因此，我们希望能够针对这些化学物质进行特定的治疗。