Role of the hypothalamus, oxidative stress and angiotensin in chronic stress

下丘脑、氧化应激和血管紧张素在慢性应激中的作用

• 批准号: nhmrc : 472680
• 负责人: Dr Pamela Davern
• 金额: $ 35.7万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-hypothalamus-oxidative-chronic-stress/99299
• 关键词: Role; hypothalamus; oxidative; stress; angiotensin

Stress can trigger life threatening cardiovascular events and its impact is much greater when blood pressure is raised. We seek to determine which chemical type of brain neuron and which region is responsible for amplifying the responses to repeated stress in an animal model that closely resembles the human form of the disease. We will focus specifically on the hypothalamus which controls the sympathetic nervous system.

压力可以引发危及生命的心血管事件，当血压升高时，其影响更大。我们试图确定哪种化学类型的脑神经元和哪个区域负责放大动物模型对重复压力的反应，该动物模型非常类似于人类的疾病形式。我们将特别关注控制交感神经系统的下丘脑。