Role of the paraventricular hypothalamus in angiotensin induced neurogenic hypertension

室旁下丘脑在血管紧张素诱导的神经源性高血压中的作用

• 批准号: nhmrc : 1043718
• 负责人: Dr Pamela Davern
• 金额: $ 29.81万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-paraventricular-hypothalamus-neurogenic-hypertension/111595
• 关键词: Role; paraventricular; hypothalamus; angiotensin; induced

Hormones released from the kidney are important for setting the level of blood pressure. We have discovered that very low levels of the peptide angiotensin in the blood also leads to activation of specific parts of the brain that drive to increase the nervous system activity to blood vessels and therefore increases blood pressure further. This study will explore the chemical signals in the brain mediating this increase in blood pressure.

从肾脏释放的激素对设定血压水平很重要。我们已经发现，血液中非常低水平的肽血管紧张素也会导致大脑特定部位的激活，从而增加神经系统对血管的活动，从而进一步增加血压。这项研究将探索大脑中介导血压升高的化学信号。