Essential equipment for nanoparticle characterization: stability, surface chemistry and optical properties

纳米粒子表征的基本设备：稳定性、表面化学和光学特性

• 批准号: 344705-2007
• 负责人: Ma, Dongling
• 金额: $ 6万
• 依托单位: Institut national de la recherche scientifique
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=363500
• 关键词: Essential; equipment; nanoparticle; characterization; stability

Nanomaterials (size scale: 1-100 nm) with their novel properties unique to matter of such dimensions are creating new routes to many pressing biomedical issues. For this reason, I have been recently hired by INRS to pursue a vigorous research program in the development of highly functional nanoparticles (NPs) possessing luminescent and/or superparamagnetic properties and targeted at various important biomedical applications.  The short-term objective of the proposed research is to develop hybrid NPs based on semiconductor NPs (emitting in both visible and near-infrared regions) and/or metallic superparamagnetic NPs (for highest magnetization and thus working efficiency), which will be covered by robust shells (e.g. polymer/silica double shells, for stability and minimal toxicity). The main thrust of our activity will focus on advanced nanomaterials synthesis, surface modification and conjugation, structural and stability characterization, and the investigation of superparamagnetic and photophysical properties using a combination of experimental techniques. The long-term objectives are increasing our knowledge of luminescent and superparamagnetic nanomaterials as well as pushing them towards biomedical applications.  State-of-the-art equipment for NP characterization is essential to develop the proposed research program. One of the most important equipment is a Ultraviolet (UV)/Visible (Vis)/Near-infrared (NIR) Spectrophotometer to be used for the optical characterization of luminescent NPs and for the convenient determination of the concentrations of species of interest during surface modification and conjugation processes. It is also absolutely crucial to have a Zeta Potential Analyzer that is able to test and optimize the colloidal stability of NPs and evaluate their surface chemistry after surface modification. The present application will complement funding from other sources, with the aim of contributing to foster focused research activities in advanced nanomaterials development and characterization and to train highly qualified personnel to respond to contemporary scientific and technological challenges.

纳米材料（尺寸比例：1-100 nm），其独特的新特性，这种尺寸的物质正在创造新的途径，许多紧迫的生物医学问题。基于这个理由，我最近被INRS聘用，从事一项积极的研究计划，开发具有发光和/或超顺磁特性的高功能纳米颗粒（NPs），并针对各种重要的生物医学应用。拟议研究的短期目标是开发基于半导体NPs的混合NPs纳米颗粒可以是金属超顺磁性纳米颗粒（在可见光和近红外区域两者中发射）和/或金属超顺磁性纳米颗粒（用于最高的磁化和因此的工作效率），其将被坚固的壳（例如聚合物/二氧化硅双壳，用于稳定性和最小的毒性）覆盖。我们的活动的主要推力将集中在先进的纳米材料合成，表面改性和共轭，结构和稳定性表征，以及超顺磁性和磁物理性质的调查，使用实验技术的组合。长期目标是增加我们对发光和超顺磁性纳米材料的了解，并将其推向生物医学应用。最先进的NP表征设备对于开发拟议的研究计划至关重要。最重要的设备之一是紫外（UV）/可见光（维斯）/近红外（NIR）分光光度计，用于发光NP的光学表征，并用于在表面改性和缀合过程中方便地测定感兴趣物质的浓度。拥有Zeta电位分析仪也绝对至关重要，该分析仪能够测试和优化NP的胶体稳定性，并在表面改性后评估其表面化学。本申请将补充来自其他来源的资金，目的是促进在先进纳米材料开发和表征方面开展重点突出的研究活动，并培训高素质的人员，以应对当代科学和技术挑战。