Studies of aggregated molecules near electrode surfaces

电极表面附近聚集分子的研究

• 批准号: 203356-2006
• 负责人: Bizzotto, Dan
• 金额: $ 3.16万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=364060
• 关键词: Studies; aggregated; molecules; near; electrode

Recent advances in the understanding of the nature of molecules near an electrode surface at very negative potentials has been possible through the use of fluorescence microscopy performed in an electrochemical environment.  These desorbed molecules exist in a unique environment which has been shown through the use of impedance and spectroscopy.  This proposal will examine methods for manipulating these molecules through the use of electric fields and optical tweezers.  In both cases, the external perturbation will be used to exert a force on these molecules in order to displace then in a lateral fashion.  Measurement of the forces required to do this will enhance the understanding of the nature of the forces holding the molecules near but not on the electrode surface at the extreme values of potential.  This system will also be used for the delivery of a small amount of molecules to a particular location through the use of microelectrodes.  Together these two approaches will allow us to construct methodologies for utilizing this unique interface in biosensor or bio-mimetic devices that may be part of a lab-on-a-chip analysis system.

在电化学环境中使用荧光显微镜，可以了解电极表面附近的分子在非常负电位下的性质。这些解吸分子存在于一个独特的环境中，这一点已经通过使用阻抗和光谱学显示出来。本建议将研究通过使用电场和光学操纵这些分子的方法镊子。在这两种情况下，外部扰动将用于对这些分子施加力，以便以横向方式移动。测量这样做所需的力将增强对在电势极值时将分子保持在电极表面附近而不是电极表面上的力的性质的理解。该系统还将用于输送少量的这两种方法将使我们能够构建在生物传感器或生物模拟装置中利用这种独特界面的方法，这些生物传感器或生物模拟装置可以是芯片实验室分析系统的一部分。