Regulation of the Drosophila c-Myc homologue in stem cell growth and division.

果蝇 c-Myc 同源物在干细胞生长和分裂中的调节。

• 批准号: nhmrc : 628414
• 负责人: A/Pr Gary Hime
• 金额: $ 40.9万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-drosophila-c-growth-division/83157
• 关键词: Regulation; Drosophila; Myc; homologue; stem

The mechanisms controlling stem cell growth and division require elucidation if we are to use stem cells in regenerative medicine and find cancer treatments. Due to experimental limitations such mechanisms are largely unknown in humans. We aim to use the vinegar fly as a model system to understand the importance of microenvironment to cancer gene control in stem cells. We will identify the secreted signals, from the neighbouring cells, required to control cancer initiation in stem cells.

如果我们要在再生医学中使用干细胞并找到癌症治疗方法，那么控制干细胞生长和分裂的机制需要阐明。由于实验的限制，这些机制在人类中基本上是未知的。我们的目标是使用醋蝇作为模型系统来了解微环境对干细胞中癌症基因控制的重要性。我们将识别来自邻近细胞的分泌信号，这些信号是控制干细胞中癌症发生所必需的。