RNA binding protein Musashi: role in folliculogenesis and oocyte development

RNA 结合蛋白 Musashi：在卵泡发生和卵母细胞发育中的作用

• 批准号: nhmrc : 569234
• 负责人: A/Pr Gary Hime
• 金额: $ 27.95万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/rna-binding-protein-oocyte-development/77512
• 关键词: RNA; binding; protein; Musashi; role

Women in Australian have opted for social and economic reasons to delay both marriage and childbirth. Both infertility and congenital abnormality is associated with advancing maternal age as the ovarian pool of oocytes declines in number and quality. In this project we aim to gain an understanding of the molecular mechanisms underpinning healthy oocyte development. Insights gained have the potential to alleviate miscarriage, infertility and congenital abnormalities in Australian families.

澳大利亚女性选择推迟结婚和生育是出于社会和经济原因。不孕症和先天异常都与母亲年龄的增加有关，因为卵巢卵母细胞池在数量和质量上都有所下降。在这个项目中，我们的目标是了解支持健康卵母细胞发育的分子机制。所获得的见解有可能减轻澳大利亚家庭的流产、不孕不育和先天畸形。