Functional studies on the role of DNp73 in stem cells and cancer
Functional studies on the role of DNp73 in stem cells and cancer
批准号:
nhmrc : 1010429
负责人:
A/Pr Gary Hime
金额:
$28.59万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31
中文摘要
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英文摘要
This project investigates the role of the p73 gene in regulating stem cells and facilitating intestinal cancer formation. We hypothesize that when a particular form of this gene (DNp73) is upregulated it prevents differentiation of stem cells and promotes tumour formation. We combine novel approaches in mice and fruit flies to examine the function of DNp73 in stem cells with analysis of human tumour samples. These studies may identify a new target for tumour therapy.
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会议论文
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批准号:nhmrc : 1100531
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项目类别:Project Grants
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资助金额:$44.34万
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财政年份:2016
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负责人:A/Pr Gary Hime
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依托单位:
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批准号:nhmrc : 1048110
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项目类别:Project Grants
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财政年份:2013
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依托单位:
Regulation of the Drosophila c-Myc homologue in stem cell growth and division.
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批准号:nhmrc : 628414
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项目类别:NHMRC Project Grants
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资助金额:$40.9万
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财政年份:2010
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依托单位:
RNA binding protein Musashi: role in folliculogenesis and oocyte development
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批准号:nhmrc : 569234
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项目类别:NHMRC Project Grants
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资助金额:$27.95万
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财政年份:2009
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负责人:A/Pr Gary Hime
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依托单位:
The role of Snail family proteins in stem cells and tumour growth
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批准号:nhmrc : 509158
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项目类别:NHMRC Project Grants
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资助金额:$39.29万
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财政年份:2008
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负责人:A/Pr Gary Hime
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依托单位:
Australian Drosophila Biomedical Research Support Facility
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批准号:nhmrc : 418033
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项目类别:NHMRC Enabling Grants
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资助金额:$67.27万
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财政年份:2007
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负责人:A/Pr Gary Hime
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依托单位:
Genetic Models of Cancer Development and Treatment
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批准号:nhmrc : 350316
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财政年份:2005
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依托单位:
Discovery of novel oncogenes and tumour suppressor genes via genetic interactions with Drosophila Cbl.
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财政年份:2002
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依托单位:
A genetic and functional analysis of the Cbl proto-oncogene in Drosophila.
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财政年份:1999
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依托单位:
国内基金
海外基金
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批准号:82371528
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项目类别:面上项目
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资助金额:49.00万元
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批准年份:2023
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负责人:李媛
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依托单位:
星形胶质细胞介导的髓鞘吞噬参与慢性脑低灌注白质损伤的机制研究
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批准号:82371307
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项目类别:面上项目
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资助金额:49.00万元
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批准年份:2023
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负责人:汤耀辉
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依托单位: