The role of Snail family proteins in stem cells and tumour growth

蜗牛家族蛋白在干细胞和肿瘤生长中的作用

• 批准号: nhmrc : 509158
• 负责人: A/Pr Gary Hime
• 金额: $ 39.29万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-snail-family-tumour-growth/78396
• 关键词: role; Snail; family; proteins; stem

This project investigates the role of a family of genes in regulating stem cells in normal tissues and cancer. This family can switch other genes off and we hypothesize that keeping these genes off is required to allow stem cells to be maintained in tissues. We combine novel studies in fruit flies and mice to examine gene function in stem cells and tumour initiation. These studies will increase our knowledge of how to manipulate stem cells and may identify new targets for tumour therapy.

这个项目调查了一个基因家族在调节正常组织和癌症中的干细胞中的作用。这个家族可以关闭其他基因，我们假设，关闭这些基因是允许干细胞在组织中保持的必要条件。我们结合了在果蝇和小鼠身上的新研究，以检查干细胞中的基因功能和肿瘤启动。这些研究将增加我们对如何操纵干细胞的了解，并可能为肿瘤治疗确定新的靶点。