Role of Snail family proteins in male fertility and testicular cancer

蜗牛家族蛋白在男性生育能力和睾丸癌中的作用

• 批准号: nhmrc : 1048110
• 负责人: A/Pr Gary Hime
• 金额: $ 39.08万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-snail-family-testicular-cancer/112001
• 关键词: Role; Snail; family; proteins; male

Male fertility requires production of healthy sperm in the testis. This project builds on our discoveries that testicular cells regulate gene activity via the Snail family of proteins during sperm development, and that interruption of their activities reduces fertility in mice and fruitflies. Snail proteins are also active in cancer cells. We propose to study the precise steps in sperm production affected by Snail proteins and how they affect the progression of testicular cancer.

男性的生育能力需要在睾丸中产生健康的精子。这个项目建立在我们的发现之上，即睾丸细胞在精子发育过程中通过蜗牛蛋白家族调节基因活动，而它们的活动中断会降低小鼠和果蝇的生育能力。蜗牛蛋白在癌细胞中也很活跃。我们建议研究蜗牛蛋白影响精子产生的精确步骤，以及它们如何影响睾丸癌的进展。