Role of Snail proteins in mediating intestinal stem cell identity

Snail 蛋白在介导肠道干细胞身份中的作用

• 批准号: nhmrc : 1100531
• 负责人: A/Pr Gary Hime
• 金额: $ 44.34万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-snail-proteins-cell-identity/662516
• 关键词: Role; Snail; proteins; mediating; intestinal

The lining of the intestine is constantly renewed by stem cells which also contribute to replenishment of this layer following damage caused by trauma, infection or treatments such as chemotherapy. We are studying how a family of gene regulators called Snail proteins act to maintain stem cells in the gut. Snail proteins have also been found to be present at high levels in bowel tumours so we are examining their role in the genesis of tumours and resistance to common treatments.

肠的衬里不断地被干细胞更新，干细胞也有助于在创伤、感染或化疗等治疗造成的损伤后补充这一层。我们正在研究一个名为Snail蛋白的基因调控家族如何发挥作用，以维持肠道中的干细胞。蜗牛蛋白也被发现在肠道肿瘤中以高水平存在，因此我们正在研究它们在肿瘤发生和对常见治疗的抵抗中的作用。