Humoral Immunity: From Regulation to Dysregulation

体液免疫：从调节到失调

• 批准号: 10469165
• 负责人: Thale Cross Jarvis
• 金额: $ 0.4万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-21 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10469165
• 关键词: Address; Affinity; Allergic; Allergic Disease; Antibodies; Antibody Response; Antigens; Area; Autoantigens; Autoimmune Diseases; Autoimmunity; Automobile Driving; B-Lymphocytes; Cells; Chronic; Collaborations; Communities; Complex; Development; Diagnostic; Educational workshop; Feedback; Fostering; Future; Generations; Genetic Screening; Genomics; Germany; Goals; Heart; Humoral Immunities; Immune; Immune System Diseases; Immune response; Infection; Inflammatory; Investigation; Knowledge; Lead; Learning; Ligands; Memory B-Lymphocyte; Mentors; Methodology; Methods; Outcome; Participant; Pathologic; Pathology; Pathway interactions; Play; Process; Reaction; Regulation; Research; Research Personnel; Scientist; Structure of germinal center of lymph node; T-Lymphocyte; Time; Tissues; Vaccine Design; Vaccines; Work; acute infection; adaptive immune response; career; career development; chronic infection; clinical practice; commensal microbes; design; imaging genetics; innovation; interest; knowledge base; novel; pathogen; plasma cell differentiation; posters; receptor; response; secondary lymphoid organ; symposium; tool; vaccine response

ABSTRACT Support is requested for a Keystone Symposia conference entitled Humoral Immunity: From Regulation to Dysregulation, organized by Drs. Victor L.J. Tybulewicz, Kai-Michael Toellner, Julie Zikherman and Pamela Schwartzberg. The conference will be held in Hannover, Germany from April 3-6, 2022. Humoral immunity is at the heart of the adaptive immune response. The germinal center reaction orchestrates critical B cell-T cell collaboration, leading to the generation of B cell memory and long-lived affinity-matured protective antibodies. This key immune response has been extensively studied, and, as a result, there has been an increasingly refined understanding of the ligands, receptors, and intra-cellular pathways that are involved in this process. However, many aspects of this remarkable process, as it plays out in infections, vaccine responses, and chronic immunological diseases, remain unknown. For instance, there is no clear understanding on how B cells integrate complex antigenic and co-stimulatory inputs over time to make critical cell fate decisions, including the process of clonal selection in the germinal center as well as memory B cell and long-lived plasma cell differentiation. Additionally, there is not a full appreciation for the spectrum of ‘non- canonical’ B cell responses to various chronic and acute infections, especially those occurring in tissues rather than secondary lymphoid organs. And finally, many unanswered questions remain about normal and abnormal B cell responses to commensal flora, allergic antigens, and self-antigens that are essential to address if researchers hope to understand dysregulated B cell immune responses in inflammatory, allergic, and autoimmune diseases. Therefore, this conference brings together scientists focused on both the B cell and the Tfh cell contributions to humoral immunity in order to share innovative research focused on addressing this broad set of questions. It is a goal of this conference to identify areas of future investigation, foster collaboration, and collectively generate the knowledge base required to design better vaccines and more precise strategies to treat diseases of immune dysregulation.

抽象的 请求支持题为“体液免疫：从监管到 失调，由博士组织。 Victor L.J. Tybulewicz、Kai-Michael Toellner、Julie Zikherman 和 Pamela 施瓦茨伯格。会议将于2022年4月3日至6日在德国汉诺威举行。 体液免疫是适应性免疫反应的核心。生发中心反应协调 关键的 B 细胞-T 细胞协作，导致 B 细胞记忆的产生和长寿命的亲和力成熟 保护性抗体。这一关键的免疫反应已被广泛研究，因此， 对配体、受体和细胞内途径的了解日益深入 参与这个过程。然而，这一非凡过程的许多方面，正如它在感染中所表现的那样， 疫苗反应和慢性免疫疾病仍然未知。例如，没有明确的规定 了解 B 细胞如何随着时间的推移整合复杂的抗原和共刺激输入，从而发挥关键作用 细胞命运决定，包括生发中心和记忆 B 细胞的克隆选择过程 和长寿命的浆细胞分化。此外，对于“非非”的范围还没有充分的认识。 B 细胞对各种慢性和急性感染的典型反应，尤其是那些发生在组织中的感染 高于次级淋巴器官。最后，关于正常和异常的许多未解答的问题仍然存在 B 细胞对共生菌群、过敏性抗原和自身抗原的反应对于解决以下问题至关重要： 研究人员希望了解炎症、过敏和其他疾病中失调的 B 细胞免疫反应。 自身免疫性疾病。因此，本次会议汇集了关注 B 细胞和 Tfh 细胞对体液免疫的贡献，以便分享专注于解决这一问题的创新研究 一系列广泛的问题。本次会议的目标是确定未来研究的领域，促进 协作，共同生成设计更好的疫苗等所需的知识库 治疗免疫失调疾病的精确策略。