Humoral Immunity: From Regulation to Dysregulation

体液免疫：从调节到失调

• 批准号: 10469165
• 负责人: Thale Cross Jarvis
• 金额: $ 0.4万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-21 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10469165
• 关键词: Address; Affinity; Allergic; Allergic Disease; Antibodies; Antibody Response; Antigens; Area; Autoantigens; Autoimmune Diseases; Autoimmunity; Automobile Driving; B-Lymphocytes; Cells; Chronic; Collaborations; Communities; Complex; Development; Diagnostic; Educational workshop; Feedback; Fostering; Future; Generations; Genetic Screening; Genomics; Germany; Goals; Heart; Humoral Immunities; Immune; Immune System Diseases; Immune response; Infection; Inflammatory; Investigation; Knowledge; Lead; Learning; Ligands; Memory B-Lymphocyte; Mentors; Methodology; Methods; Outcome; Participant; Pathologic; Pathology; Pathway interactions; Play; Process; Reaction; Regulation; Research; Research Personnel; Scientist; Structure of germinal center of lymph node; T-Lymphocyte; Time; Tissues; Vaccine Design; Vaccines; Work; acute infection; adaptive immune response; career; career development; chronic infection; clinical practice; commensal microbes; design; imaging genetics; innovation; interest; knowledge base; novel; pathogen; plasma cell differentiation; posters; receptor; response; secondary lymphoid organ; symposium; tool; vaccine response

ABSTRACT Support is requested for a Keystone Symposia conference entitled Humoral Immunity: From Regulation to Dysregulation, organized by Drs. Victor L.J. Tybulewicz, Kai-Michael Toellner, Julie Zikherman and Pamela Schwartzberg. The conference will be held in Hannover, Germany from April 3-6, 2022. Humoral immunity is at the heart of the adaptive immune response. The germinal center reaction orchestrates critical B cell-T cell collaboration, leading to the generation of B cell memory and long-lived affinity-matured protective antibodies. This key immune response has been extensively studied, and, as a result, there has been an increasingly refined understanding of the ligands, receptors, and intra-cellular pathways that are involved in this process. However, many aspects of this remarkable process, as it plays out in infections, vaccine responses, and chronic immunological diseases, remain unknown. For instance, there is no clear understanding on how B cells integrate complex antigenic and co-stimulatory inputs over time to make critical cell fate decisions, including the process of clonal selection in the germinal center as well as memory B cell and long-lived plasma cell differentiation. Additionally, there is not a full appreciation for the spectrum of ‘non- canonical’ B cell responses to various chronic and acute infections, especially those occurring in tissues rather than secondary lymphoid organs. And finally, many unanswered questions remain about normal and abnormal B cell responses to commensal flora, allergic antigens, and self-antigens that are essential to address if researchers hope to understand dysregulated B cell immune responses in inflammatory, allergic, and autoimmune diseases. Therefore, this conference brings together scientists focused on both the B cell and the Tfh cell contributions to humoral immunity in order to share innovative research focused on addressing this broad set of questions. It is a goal of this conference to identify areas of future investigation, foster collaboration, and collectively generate the knowledge base required to design better vaccines and more precise strategies to treat diseases of immune dysregulation.

抽象的 请求支持Keystone研讨会会议，标题为“体液免疫：从监管到 失调，由Drs组织。 Victor L.J. Tybulewicz，Kai-Michael Toellner，Julie Zikherman和Pamela Schwartzberg。会议将于2022年4月3日至6日在德国汉诺威举行。 体液免疫学是适应性免疫响应的核心。生发中心反应协调 临界B细胞-T细胞协作，导致B细胞记忆的产生和长寿的亲和力成熟 保护性抗体。这种关键的免疫反应已广泛研究，因此， 是对配体，接收器和细胞内途径的越来越精致的理解 参与此过程。但是，这种非凡过程的许多方面，因为它在感染中发挥了作用， 疫苗反应和慢性免疫疾病仍然未知。例如，没有清楚的 了解B细胞如何随着时间的推移整合复杂的抗原和共同刺激输入 细胞脂肪决策，包括生发中心的克隆选择过程以及记忆B细胞 和长寿命的浆细胞分化。此外，对非 - 非 - 规范的B细胞对各种慢性和急性感染的反应，尤其是在组织中发生的人 比继发性淋巴器官。最后，关于正常和异常的许多未解决的问题仍然存在 B细胞对共生菌群，过敏抗原和自我抗原的反应，对于解决 研究人员希望了解炎症，过敏和 自身免疫性疾病。因此，这次会议汇集了科学家，专注于B细胞和 TFH细胞对体液免疫学的贡献，以分享专注于解决此问题的创新研究 广泛的问题。该会议的目标是确定未来调查的领域，福斯特 协作，并集体生成设计更好的疫苗所需的知识库 治疗免疫失调疾病的精确策略。