Humoral Immunity: From Regulation to Dysregulation

摘要 请求支持一个题为“体液免疫：从调节到免疫”的基石研讨会。 失调，由维克托L. J. Tybulewicz、Kai-Michael Toellner、Julie Zikherman和Pamela博士组织 施瓦茨伯格会议将于2022年4月3日至6日在德国的汉诺威举行。 体液免疫是适应性免疫反应的核心。Germinal中心反应协调了 关键的B细胞-T细胞协作，导致产生B细胞记忆和长寿的亲和力成熟 保护性抗体这种关键的免疫反应已经得到了广泛的研究，因此， 对配体、受体和细胞内途径的理解越来越精细， 参与这个过程。然而，这一非凡过程的许多方面，正如它在感染中所发挥的作用， 疫苗反应和慢性免疫性疾病仍然未知。例如，没有明确的 了解B细胞如何随着时间的推移整合复杂的抗原和共刺激输入， 细胞命运决定，包括生殖中心以及记忆B细胞的克隆选择过程 和长寿的浆细胞分化。此外，没有充分认识到“非- 典型的B细胞对各种慢性和急性感染的反应，特别是那些发生在组织中的感染，而 而不是次级淋巴器官。最后，关于正常和不正常，还有许多未解之谜 B细胞对肠道植物群、过敏性抗原和自身抗原的应答，对于解决以下问题至关重要： 研究人员希望了解在炎症、过敏和免疫反应中失调的B细胞免疫反应。 自身免疫性疾病因此，这次会议汇集了专注于B细胞和 Tfh细胞对体液免疫的贡献，以分享专注于解决这一问题的创新研究 广泛的问题。本次会议的目标是确定未来调查的领域， 合作，并共同产生设计更好的疫苗所需的知识库， 治疗免疫失调疾病的精确策略。

ABSTRACT Support is requested for a Keystone Symposia conference entitled Humoral Immunity: From Regulation to Dysregulation, organized by Drs. Victor L.J. Tybulewicz, Kai-Michael Toellner, Julie Zikherman and Pamela Schwartzberg. The conference will be held in Hannover, Germany from April 3-6, 2022. Humoral immunity is at the heart of the adaptive immune response. The germinal center reaction orchestrates critical B cell-T cell collaboration, leading to the generation of B cell memory and long-lived affinity-matured protective antibodies. This key immune response has been extensively studied, and, as a result, there has been an increasingly refined understanding of the ligands, receptors, and intra-cellular pathways that are involved in this process. However, many aspects of this remarkable process, as it plays out in infections, vaccine responses, and chronic immunological diseases, remain unknown. For instance, there is no clear understanding on how B cells integrate complex antigenic and co-stimulatory inputs over time to make critical cell fate decisions, including the process of clonal selection in the germinal center as well as memory B cell and long-lived plasma cell differentiation. Additionally, there is not a full appreciation for the spectrum of ‘non- canonical’ B cell responses to various chronic and acute infections, especially those occurring in tissues rather than secondary lymphoid organs. And finally, many unanswered questions remain about normal and abnormal B cell responses to commensal flora, allergic antigens, and self-antigens that are essential to address if researchers hope to understand dysregulated B cell immune responses in inflammatory, allergic, and autoimmune diseases. Therefore, this conference brings together scientists focused on both the B cell and the Tfh cell contributions to humoral immunity in order to share innovative research focused on addressing this broad set of questions. It is a goal of this conference to identify areas of future investigation, foster collaboration, and collectively generate the knowledge base required to design better vaccines and more precise strategies to treat diseases of immune dysregulation.