Regulation of inflammation and coagulation by microparticles containing SerpinB2

含有 SerpinB2 的微粒调节炎症和凝血

• 批准号: nhmrc : 1043104
• 负责人: A/Pr Elizabeth Gardiner
• 金额: $ 39.62万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-inflammation-coagulation-containing-serpinb2/111545
• 关键词: Regulation; inflammation; coagulation; microparticles; containing

SerpinB2 is a protein that is abundant during many types of inflammation. However, what this protein actually does remains an enigma. We have found that SerpinB2 is associated with microparticles; small particles found in everyone’s blood, that are used by cells to communicate with each other. We believe inappropriate levels of SerpinB2 on these microparticles change both inflammation and blood clotting; a contention with implications for several diseases including pre-eclampsia and cancer.

SerpinB 2是一种在许多类型的炎症中丰富的蛋白质。然而，这种蛋白质实际上是什么仍然是一个谜。我们已经发现SerpinB 2与微粒有关;每个人血液中发现的小颗粒，被细胞用来相互交流。我们认为，这些微粒上SerpinB 2的不适当水平会改变炎症和凝血;这与包括先兆子痫和癌症在内的几种疾病有关。