Platelet receptor shedding in stroke and thrombosis

中风和血栓形成中的血小板受体脱落

• 批准号: nhmrc : 545861
• 负责人: A/Pr Elizabeth Gardiner
• 金额: $ 36.84万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/platelet-receptor-shedding-stroke-thrombosis/76724
• 关键词: Platelet; receptor; shedding; stroke; thrombosis

In response to tissue injury and bleeding, blood platelets use receptors to form a thrombus (blood clot) and block further loss of blood and aid tissue repair. In inflammation or disease, abberant platelet activation can form a thrombus within cerebral (stroke) or coronary vessels (heart attack). We examine how a thrombus-limiting step (platelet receptor shedding) is triggered in thrombus-forming platelets, and if shed receptor can be used as a blood marker of abberant platelet activation.

作为对组织损伤和出血的反应，血小板利用受体形成血栓(血块)，阻止进一步的血液流失，帮助组织修复。在炎症或疾病中，异常的血小板激活可在脑血管(中风)或冠状动脉(心脏病发作)内形成血栓。我们研究了血栓形成中血栓限制步骤(血小板受体脱落)是如何被触发的，以及脱落受体是否可以用作抑制血小板激活的血液标记物。