Platelet receptor regulation in autoimmune disease

作为对出血的反应，血小板利用受体形成血栓（血块），阻止血液进一步流失，帮助组织修复。术前接受肝素治疗的患者可形成攻击血小板的自身抗体，导致血栓和血小板减少（危险的循环血小板损失）。这是一个难以诊断的重大临床问题。我们将确定血小板受体脱落如何帮助肝素诱导的血小板减少症的诊断。

In response to bleeding, blood platelets use receptors to form a thrombus (blood clot) and block further loss of blood and aid tissue repair. People treated with heparin prior to surgery, can form autoantibodies that attack platelets, leading to thombus and thrombocytopenia (dangerous loss of circulating platelets). This is a significant clinical problem that is difficult to diagnose. We will determine how platelet receptor shedding can aid the diagnosis of heparin-induced thrombocytopenia.