Research Fellowship

研究奖学金

• 批准号: nhmrc : 1042865
• 负责人: A/Pr Elizabeth Gardiner
• 金额: $ 50.1万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/research-fellowship/111520
• 关键词: Research; Fellowship

Platelets are key blood elements that are essential for the prevention of bleeding in response to injury or infection. Overactive or spontaneously active platelets cause thrombosis and blood clot formation. My laboratory has identified new physiological pathways of activation of platelet metalloproteinases, the enzymes that regulate surface levels of the prothrombotic platelet receptors. By understanding this mechanism of receptor regulation, we can uniquely target platelet receptors in people with prothrombotic pathologies.

血小板是预防因损伤或感染而出血所必需的关键血液元素。血小板过度活化或自发活化会导致血栓形成和血凝块形成。我的实验室已经确定了血小板金属蛋白酶激活的新的生理途径，这种酶调节血栓前血小板受体的表面水平。通过了解这种受体调节机制，我们可以在血栓前病变的人中独特地靶向血小板受体。