Pathobiology that causes fatal thrombosis in HIT

导致 HIT 致命性血栓形成的病理生物学

• 批准号: nhmrc : GNT1143539
• 负责人: A/Pr Elizabeth Gardiner
• 金额: $ 39.84万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pathobiology-causes-fatal-thrombosis-hit/1348537
• 关键词: Pathobiology; causes; fatal; thrombosis; HIT

Autoimmune-based thrombocytopenia can be a life-threatening adverse event associated with viral load, surgery, drug therapies or the use of the anticoagulant, heparin. This grant will define mechanisms of anti-platelet antibody-dependent platelet activation and assess shedding of platelet-specific glycoprotein (GP)VI as an immediate consequence of this activation, provide a new strategy for evaluating risk of thrombosis in HIT.

基于自身免疫的血小板减少症可能是与病毒载量、手术、药物治疗或使用抗凝剂肝素相关的危及生命的不良事件。该基金将确定抗血小板抗体依赖性血小板活化的机制，并评估血小板特异性糖蛋白（GP）VI的脱落作为这种活化的直接后果，为评估HIT中血栓形成的风险提供新的策略。