The contribution of hypoxia to equine dermal scarring

缺氧对马皮肤疤痕的影响

• 批准号: 250231-2007
• 负责人: Theoret, Christine
• 金额: $ 2.38万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=366314
• 关键词: contribution; hypoxia; equine; dermal; scarring

Traumatic wounds frequently afflict horses, with healing complicated by the development of "proud flesh" leading to extensive scar tissue when these wounds are located on the limb, whilst body wounds tend to repair uneventfully. Impaired healing on the limb poses considerable welfare implications and bears a significant financial impact on the equine industry via the number of horses retired from an athletic career because of extensive scars or persisting lameness.The long term goal of my research program is to clarify some of the basic mechanisms of pathological scarring in the horse. Based on new findings uncovered during my current NSERC Discovery Grant, I suggest that deficient oxygen levels in the wound's microenvironment may contribute to extensive scarring in the horse, as it appears to in man. This proposal aims to verify the inherent response to hypoxia of normal skin cells from the body and the limb; to measure the oxygenation status of wounds of the body, wounds of the limb and wounds having developed proud flesh; and finally, to test the effect of a therapy purported to block the detrimental response of cells to hypoxia.This work will not only help determine some of the mechanisms involved in equine proud flesh, but will also provide a valuable tool to study scarring. Furthermore, data obtained herein may contribute to the development of novel therapeutic approaches for controlling scarring in various organs, in both veterinary species and man.

创伤性伤口经常折磨马，当这些伤口位于肢体上时，由于“骄傲的肉”的发展导致广泛的疤痕组织的愈合变得复杂，而身体伤口往往会顺利修复。肢体愈合不良造成了相当大的福利影响，并承担了显着的经济影响，通过马从运动生涯中退休，因为广泛的疤痕或持续lameless.The我的研究计划的长期目标是澄清一些马病理性疤痕的基本机制。基于我目前的NSERC发现资助期间发现的新发现，我认为伤口微环境中的缺氧水平可能会导致马的广泛疤痕，就像在人身上一样。测量身体伤口、肢体伤口和已长出赘肉的伤口的氧合状态;最后，测试一种据称可以阻断细胞对缺氧的有害反应的疗法的效果。这项工作不仅有助于确定马骄傲肉的一些机制，而且还将为研究疤痕提供有价值的工具。此外，本文获得的数据可能有助于开发新的治疗方法，用于控制兽医物种和人类的各种器官中的瘢痕形成。