The role of chemokine signalling in maintenance of the latent HIV reservoir

趋化因子信号传导在维持潜伏 HIV 储存库中的作用

• 批准号: nhmrc : 1114265
• 金额: $ 6.3万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-chemokine-signalling-hiv-reservoir/663311
• 关键词: role; chemokine; signalling; maintenance; latent

HIV cure research aims to eliminate cells with HIV in their DNA. These cells have higher levels of a receptor, CCR6, signalling through which causes migration to and concentration in the gut. This gut migration may help to maintain the HIV reservoir by bringing susceptible cells close to infected cells. We will assess the effect of blocking CCR6 signalling on the ability to infect these cells with HIV in the laboratory and its effect on the reservoir of an analogous virus in macaques.

艾滋病毒治愈研究旨在消除DNA中含有艾滋病毒的细胞。这些细胞有较高水平的受体CCR6，通过该信号导致迁移到肠道并在肠道中聚集。这种肠道迁移可能会使易感细胞接近感染细胞，从而有助于维持艾滋病毒的储存库。我们将在实验室中评估阻断CCR6信号对这些细胞感染艾滋病毒的能力的影响，以及它对猕猴体内类似病毒储存库的影响。