The role of chemokine signalling in maintenance of the latent HIV reservoir

趋化因子信号传导在维持潜伏 HIV 储存库中的作用

• 批准号: nhmrc : GNT1114265
• 负责人: Dr Matthew Pitman
• 金额: $ 9.22万
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-chemokine-signalling-hiv-reservoir/1346900
• 关键词: role; chemokine; signalling; maintenance; latent

HIV cure research aims to eliminate cells with HIV in their DNA. These cells have higher levels of a receptor, CCR6, signalling through which causes migration to and concentration in the gut. This gut migration may help to maintain the HIV reservoir by bringing susceptible cells close to infected cells. We will assess the effect of blocking CCR6 signalling on the ability to infect these cells with HIV in the laboratory and its effect on the reservoir of an analogous virus in macaques.

HIV 治愈研究旨在消除 DNA 中携带 HIV 的细胞。这些细胞具有较高水平的受体 CCR6，通过该受体发出信号导致迁移到肠道并在肠道中集中。这种肠道迁移可能通过使易感细胞靠近受感染的细胞来帮助维持艾滋病毒储存库。我们将评估在实验室中阻断 CCR6 信号传导对 HIV 感染这些细胞的能力的影响，以及它对猕猴中类似病毒储存库的影响。