Regenerating the kidney using an understanding of normal development

利用对正常发育的理解来再生肾脏

• 批准号: nhmrc : GNT1136085
• 负责人: Prof Melissa Little
• 金额: $ 95.1万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regenerating-kidney-using-normal-development/1348028
• 关键词: Regenerating; kidney; using; understanding; normal

In Australia, chronic kidney disease costs >$1 billion per annum, however treatment options for kidney failure have not changed for >50 years. Dialysis reduces quality of life and lifespan while only 1 in 4 patients receives a transplant. Using our understanding of normal kidney formation, this study will generate kidney tissue from human stem cells to better understand inherited kidney diseases and develop novel regenerative therapies for the treatment of end stage kidney disease.

在澳大利亚，慢性肾病每年花费超过 10 亿美元，但肾衰竭的治疗选择超过 50 年没有改变。透析会降低生活质量和寿命，而只有四分之一的患者接受移植。利用我们对正常肾脏形成的理解，这项研究将从人类干细胞中产生肾脏组织，以更好地了解遗传性肾脏疾病，并开发治疗终末期肾脏疾病的新型再生疗法。