Kidney mesenchymal stem cells in tubular development, repair and turnover

肾间充质干细胞在肾小管发育、修复和周转中的作用

• 批准号: nhmrc : 1054985
• 负责人: Prof Melissa Little
• 金额: $ 65.96万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Targeted Calls
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/kidney-mesenchymal-stem-repair-turnover/112425
• 关键词: Kidney; mesenchymal; stem; cells; tubular

In Australia, 11.3% of deaths are associated with chronic kidney disease with >$1 billion per annum spent on treating this condition. At present, only dialysis and transplantation are available to treat end stage kidney disease. We have found a kidney stem cell population in both human and mouse that can form new epithelial structures. In this project, we will investigate the normal role played by these kidney stem cells and examine whether they can contribute to kidney regeneration.

在澳大利亚，11.3%的死亡与慢性肾脏疾病有关，每年用于治疗这种疾病的费用为10亿美元。目前，只有透析和移植可用于治疗终末期肾病。我们已经在人类和小鼠中发现了一个肾脏干细胞群，它可以形成新的上皮结构。在这个项目中，我们将研究这些肾脏干细胞所发挥的正常作用，并检查它们是否有助于肾脏再生。