Reprogramming the renal epithelium to reinitiate nephrogenesis

重新编程肾上皮以重新启动肾发生

• 批准号: nhmrc : 631362
• 负责人: Prof Melissa Little
• 金额: $ 42.42万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/reprogramming-renal-epithelium-reinitiate-nephrogenesis/94829
• 关键词: Reprogramming; renal; epithelium; reinitiate; nephrogenesis

It has been shown that a mature cell type can be reprogrammed to a different type of cell in vivo via the introduction of genes critical during an earlier stage of organ development. In this way, new beta-islet cells in the pancreas can be made. In this study, we will use our understanding of kidney development to redirect the cells of the kidney tubules to dedifferentiate and form new nephrons. This may ultimately result in a regenerative strategy to treat chronic renal disease.

已经表明，通过在器官发育的早期阶段引入关键基因，成熟细胞类型可以在体内重编程为不同类型的细胞。通过这种方式，可以在胰腺中产生新的β-胰岛细胞。在这项研究中，我们将利用我们对肾脏发育的理解来重新定向肾小管细胞去分化并形成新的肾单位。这可能最终导致治疗慢性肾脏疾病的再生策略。