The role of GAPDH acetylation and HDAC6 in liver metabolism and type 2 diabetes

2型糖尿病（T2D）的特征是血糖水平持续升高。通过不受控制的葡萄糖合成和释放，肝脏代谢改变是T2D患者血糖水平升高的关键因素。该项目将研究一种名为GAPDH的代谢酶通过乙酰化过程的调节是否有助于正常的肝脏葡萄糖代谢。该项目还将评估GAPDH乙酰化改变是否会导致T2D的高血糖。

Type 2 diabetes (T2D) is characterised by persistent elevated blood glucose levels. Altered liver metabolism is a key contributor to elevated blood glucose levels in T2D, through uncontrolled synthesis and release of glucose. This project will examine whether regulation of a metabolic enzyme called GAPDH by a process termed acetylation, contributes to normal liver glucose metabolism. This project will also assess whether altered GAPDH acetylation contributes to hyperglycaemia in T2D.