Activation of HSP72 in skeletal muscle as a therapeutic target for obesity

激活骨骼肌中的 HSP72 作为肥胖治疗靶点

• 批准号: nhmrc : 1004441
• 负责人: A/Pr Clinton Bruce
• 金额: $ 43.74万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/activation-hsp72-skeletal-target-obesity/109034
• 关键词: Activation; HSP72; skeletal; muscle; therapeutic

We recently discovered that activation of a protein, namely Heat Shock Protein 72, can prevent obesity and insulin resistance in mice. We have developed a small molecule activator of this protein which has undergone preliminary human clinical trials. This project will extend upon this initial finding to determine the precise mechanism by which activation of this protein prevents obesity and insulin resistance.

我们最近发现，激活一种蛋白质，即热休克蛋白72，可以防止小鼠肥胖和胰岛素抵抗。我们已经开发出这种蛋白的小分子激活剂，已经进行了初步的人体临床试验。该项目将在这一初步发现的基础上继续研究，以确定激活该蛋白以防止肥胖和胰岛素抵抗的确切机制。