Impaired respiratory tolerance in obesity - the link with asthma?

肥胖导致的呼吸耐受力受损——与哮喘的关系？

• 批准号: nhmrc : 1027459
• 负责人: A/Pr Clinton Bruce
• 金额: $ 44.5万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/impaired-respiratory-tolerance-link-asthma/110570
• 关键词: Impaired; respiratory; tolerance; obesity; link

Australia has one of the highest obesity rates in the world, placing a major strain on health budgets. Obesity increases the risk of numerous diseases, including asthma. Asthma is prevented in healthy people by the immune system. This project will investigate whether obesity-related dietary factors and/or gut microbes impair this immune-mediated mechanism. Outcomes will increase understanding of the effects of diet and obesity on asthma development, and lead to novel asthma therapies.

澳大利亚是世界上肥胖率最高的国家之一，这给卫生预算带来了巨大压力。肥胖增加了许多疾病的风险，包括哮喘。健康人群的免疫系统可以预防哮喘。该项目将研究肥胖相关的饮食因素和/或肠道微生物是否会损害这种免疫介导的机制。结果将增加对饮食和肥胖对哮喘发展的影响的理解，并导致新的哮喘治疗方法。