Sphingosine kinase: a target for obesity-induced insulin resistance

鞘氨醇激酶：肥胖引起的胰岛素抵抗的靶标

• 批准号: nhmrc : 1023570
• 负责人: A/Pr Clinton Bruce
• 金额: $ 41.8万
• 依托单位: Deakin University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/sphingosine-kinase-target-insulin-resistance/110283
• 关键词: Sphingosine; kinase; target; obesity; induced

Insulin resistance, a characteristic of type 2 diabetes, is linked to abnormal metabolism of lipid (fat) in tissues such as liver and muscle. This project aims to identify a novel pathway which may promote a build up of lipids in liver and therefore leads to the development of type 2 diabetes. This work may provide a basis for understanding and optimizing treatment of insulin resistance by regulating the control of fat metabolism in liver.

胰岛素抵抗是 2 型糖尿病的一个特征，与肝脏和肌肉等组织中脂质（脂肪）代谢异常有关。该项目旨在确定一种新的途径，该途径可能促进肝脏中脂质的积累，从而导致 2 型糖尿病的发生。这项工作可能为通过调节肝脏脂肪代谢的控制来理解和优化胰岛素抵抗的治疗提供基础。