The role of GAPDH acetylation and HDAC6 in liver metabolism and type 2 diabetes

GAPDH乙酰化和HDAC6在肝脏代谢和2型糖尿病中的作用

• 批准号: nhmrc : 1127059
• 负责人: A/Pr Clinton Bruce
• 金额: $ 43.41万
• 依托单位: Deakin University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-gapdh-acetylation-2-diabetes/947911
• 关键词: role; GAPDH; acetylation; HDAC6; liver

Type 2 diabetes (T2D) is characterised by persistent elevated blood glucose levels. Altered liver metabolism is a key contributor to elevated blood glucose levels in T2D, through uncontrolled synthesis and release of glucose. This project will examine whether regulation of a metabolic enzyme called GAPDH by a process termed acetylation, contributes to normal liver glucose metabolism. This project will also assess whether altered GAPDH acetylation contributes to hyperglycaemia in T2D.

2型糖尿病（T2D）的特征是血糖水平持续升高。通过葡萄糖的不受控制的合成和释放，肝脏代谢改变是T2D患者血糖水平升高的关键因素。该项目将研究通过称为乙酰化的过程调节称为GAPDH的代谢酶是否有助于正常的肝脏葡萄糖代谢。该项目还将评估GAPDH乙酰化改变是否会导致T2D高血糖症。