Statistical methods for genomic research

基因组研究的统计方法

• 批准号: 293295-2006
• 负责人: Beyene, Joseph
• 金额: $ 0.58万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=395902
• 关键词: Statistical; methods; genomic; research

Biologists and clinical scientists are increasingly generating high-throughput molecular data with the hope of elucidating and understanding disease mechanisms, diagnosis and prognosis. In particular, DNA microarrays are an important technologies for studying gene expression and the possible correlations with clinical outcomes. However, these high-dimensional data generated by modern and rapidly evolving technologies come with several analytical challenges that require effcient statistical and computational methodologies. My research will add new and enhanced statistical and computational tools for the analysis and integration of high-throughput molecular as well as clinical data.

生物学家和临床科学家越来越多地产生高通量分子数据，希望阐明和理解疾病机制，诊断和预后。特别是，DNA微阵列是研究基因表达和可能与临床结果相关的重要技术。然而，这些由现代和快速发展的技术产生的高维数据带来了一些分析挑战，需要有效的统计和计算方法。我的研究将为高通量分子和临床数据的分析和整合增加新的和增强的统计和计算工具。