Characterization of chemokine induced differentiation of CD8+Tcells

CD8 T 细胞趋化因子诱导分化的表征

• 批准号: 311734-2006
• 负责人: Copeland, Karen
• 金额: $ 2.26万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=396460
• 关键词: Characterization; chemokine; induced; differentiation; CD8+Tcells

CD8+ T cells recognize and kill infected cells and are an important arm of the immune system. Host factors and their effect on the ability of cells to function have been studied primarily with CD4+ T cells and macrophages. However, far less research has been performed using CD8+ T cells. We have observed that chemo-attractant cytokines induce IL-4 production and decrease IFNgamma production by CD8+ T cells. We now wish to determine how these chemokines affect cellular functions and signalling in CD8+ T cells in response to chemokines. In addition, since the chemokines have effects on both IL-4 and IFNgamma production, we wish to further examine how this is controlled.

CD 8 + T细胞识别并杀死受感染的细胞，是免疫系统的重要组成部分。宿主因素及其对细胞功能的影响主要用CD 4 + T细胞和巨噬细胞进行了研究。然而，使用CD 8 + T细胞进行的研究要少得多。我们已经观察到，化学引诱细胞因子诱导IL-4的产生并减少CD 8 + T细胞产生IFN γ。我们现在希望确定这些趋化因子如何影响CD 8 + T细胞响应趋化因子的细胞功能和信号传导。此外，由于趋化因子对IL-4和IFN γ的产生都有影响，我们希望进一步研究如何控制这一点。