Short term effects of overfeeding on metabolic risk in humans

肥胖与糖尿病、心脏病和癌症的风险增加有关。肥胖症的流行正在迅速增加，构成了对人类健康的最大威胁之一。这项研究的目的是通过在有和没有糖尿病遗传易感性的人中诱导实验性体重增加来确定肥胖和胰岛素抵抗之间密切关系的潜在机制-S。该项目将有助于确定抗糖尿病药物的新候选药物。

Obesity is associated with increased risk of diabetes, heart disease and cancer. Obesity prevalence is rapidly increasing and consitutes one of the greatest threats to human health. The aim of this study is to determine mechanism-s underlying the close relationship between obesity and insulin resistance by inducing experimental weight gain in humans with and without a genetic predisposition to diabetes. This project will help identify new candidates for anti-diabetes drugs.