Pathogenesis of cellulitis in broilers: effects of structural, biochemical, and molecular characteristics of the skin

肉鸡蜂窝织炎的发病机制：皮肤结构、生化和分子特征的影响

• 批准号: 335361-2005
• 负责人: Laarveld, Bernard
• 金额: $ 1.93万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Agriculture and Agri-Food Canada Research Partnership
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=398949
• 关键词: Pathogenesis; cellulitis; broilers; effects; structural

Cellulitis is a skin condition observed commonly in meat type poultry.  Recently, in Canada, cellulitis has become an important condemnation category both in the broiler and turkey industries.  An important epidemiological characteristic of this condition is that the rate of condemnations due to cellulitis continues to increase at an alarming rate.  The present study proposes to unravel the etiology of cellulitis in meat type poultry.  The primary goal of this project is centered on the investigation of the underlying etiology of cellulitis and finding a practical solution to the problem.  The main objectives of this research will be focused on:  1) the role of first line defense mechanisms in the skin in the pathogenesis of avian cellulitis, 2) conditions that affect the proliferation dynamics of pathogenic bacteria involved in producing cellulitis lesions, and 3) etiological factors associated with the development of cellulitis lesions in the context of environment- bacteria-host interactions.  Thorough understanding of the pathogenesis of cellulitis is crucial for the development of a strategy for the management of the problem of avian cellulitis.  It is anticipated that the knowledge gained from this research will help in developing means to control this condition.

蜂窝织炎是一种常见于肉类家禽的皮肤病。最近，在加拿大，蜂窝织炎已成为肉鸡和火鸡业的一个重要的谴责类别。这种疾病的一个重要流行病学特征是由于蜂窝织炎引起的腹泻率以惊人的速度持续增加。本研究旨在阐明肉用型家禽蜂窝织炎的病因。本项目的主要目标是调查蜂窝织炎的潜在病因，并找到一个切实可行的解决问题的办法。本研究的主要目标将集中在：1）皮肤中第一线防御机制在禽类蜂窝织炎发病机制中的作用，2）影响参与产生蜂窝织炎病变的病原菌增殖动力学的条件，以及3）在环境-细菌-宿主相互作用的背景下与蜂窝织炎病变发展相关的病因学因素。彻底了解蜂窝织炎的发病机制对于制定管理禽蜂窝织炎问题的策略至关重要。预计从本研究中获得的知识将有助于开发控制这种疾病的方法。