Elucidation of critical characteristics of clostridium perfringens and pathogen-host-environment interactions defining susceptibility of poultry to necrotic enteritis

阐明产气荚膜梭菌的关键特征以及确定家禽对坏死性肠炎易感性的病原体-宿主-环境相互作用

• 批准号: 377557-2008
• 负责人: Laarveld, Bernard
• 金额: $ 2.33万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=484217
• 关键词: Elucidation; critical; characteristics; clostridium; perfringens

Necrotic enteritis (NE) remains an important disease in poultry. Despite considerable research over the last 30 years, the issues regarding the underlying etiology of necrotic lesions in broiler chickens still remain unresolved. According to industry experts, NE is a re-emerging disease. Moreover, because of large hidden economic cost associated with sub-clinical NE, and also because of the high risk of pathogen transfer to the food chain and public health concerns, this problem is perceived among the industry experts as a major issue. NE is a problem of significant importance for the Canadian and global poultry industry. Considering the significant gaps in understanding of the pathogenesis of this disease, there is an urgent need to initiate basic research on the characteristics of pathogens and on pathogen-host interaction etiology of NE. Development of better means for controlling NE in poultry would definitely be of strategic importance.

坏死性肠炎（NE）仍然是家禽中的一种重要疾病。尽管在过去的30年里进行了大量的研究，但关于肉鸡坏死性病变的潜在病因学问题仍然没有得到解决。业内专家表示，NE是一种重新出现的疾病。此外，由于与亚临床NE相关的巨大隐性经济成本，以及病原体向食物链转移的高风险和公共卫生问题，这一问题在行业专家中被视为一个主要问题。东北是加拿大和全球家禽业的一个重要问题。鉴于对该病发病机制的认识存在较大空白，迫切需要开展NE病原菌特征及病原-宿主相互作用病原学的基础研究。开发更好的方法来控制家禽中的NE病无疑具有重要的战略意义。