Elucidation of critical characteristics of clostridium perfringens and pathogen-host-environment interactions defining susceptibility of poultry to necrotic enteritis

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Necrotic enteritis (NE) remains an important disease in poultry. Despite considerable research over the last 30 years, the issues regarding the underlying etiology of necrotic lesions in broiler chickens still remain unresolved. According to industry experts, NE is a re-emerging disease. Moreover, because of large hidden economic cost associated with sub-clinical NE, and also because of the high risk of pathogen transfer to the food chain and public health concerns, this problem is perceived among the industry experts as a major issue. NE is a problem of significant importance for the Canadian and global poultry industry. Considering the significant gaps in understanding of the pathogenesis of this disease, there is an urgent need to initiate basic research on the characteristics of pathogens and on pathogen-host interaction etiology of NE. Development of better means for controlling NE in poultry would definitely be of strategic importance.