Sleep, plasticity and neurodegeneration: Targeting sleep to improve cognition in Mild Cognitive Impairment (MCI)

睡眠、可塑性和神经退行性变：以睡眠为目标来改善轻度认知障碍 (MCI) 的认知

• 批准号: nhmrc : 1107716
• 金额: $ 36.02万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Targeted Calls
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/sleep-plasticity-neurodegeneration-impairment-mci/662996
• 关键词: Sleep; plasticity; neurodegeneration; Targeting; sleep

Older individuals with mild cognitive impairment commonly experience disturbed sleep and about 50% will convert to dementia. It is unclear whether sleep disturbance mediates cognitive decline and progression to dementia. Optimising sleep presents a novel strategy to slow disease progression. This new research program explores links between sleep and dementia to identify new biomarkers of disease progression and new targeted therapeutic approaches to improve quality of life for older Australians.

患有轻度认知障碍的老年人通常会经历睡眠障碍，约50%的人会转化为痴呆症。目前尚不清楚睡眠障碍是否介导认知能力下降和进展为痴呆症。优化睡眠是减缓疾病进展的一种新策略。这项新的研究计划探索睡眠和痴呆症之间的联系，以确定疾病进展的新生物标志物和新的有针对性的治疗方法，以改善老年澳大利亚人的生活质量。