Sperm methylation status predicts embryo and pregnancy outcomes in male obesity

精子甲基化状态可预测男性肥胖的胚胎和妊娠结局

• 批准号: nhmrc : 1088964
• 金额: $ 23.9万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/sperm-methylation-status-male-obesity/519240
• 关键词: Sperm; methylation; status; predicts; embryo

The incidence of male obesity in reproductively age men is epidemic and continually rising with close to 70% of men of reproductive age classified as overweight or obese. Male obesity is not only associated with sub fertility but also changes to pregnancy outcomes and influencing child health. This project will try to uncover the molecular changes in sperm, providing potential mechanisms for the abnormal foetal and pregnancy health seen as a result of male obesity.

育龄男性肥胖症的发病率是流行病，并不断上升，近70%的育龄男性被归类为超重或肥胖。男性肥胖不仅与生育力低下有关，而且还改变妊娠结局并影响儿童健康。该项目将试图揭示精子中的分子变化，为男性肥胖导致的异常胎儿和妊娠健康提供潜在机制。