Structure, function and regulation of A-ATPases

A-ATP酶的结构、功能和调节

• 批准号: nhmrc : 573712
• 负责人: Dr Daniela Stock
• 金额: $ 27.53万
• 依托单位: Victor Chang Cardiac Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structure-function-regulation-a-atpases/100585
• 关键词: Structure; function; regulation; ATPases

Proton translocating ATPases are central to biological energy conversion, one of the most fundamental biological processes on earth whose elucidation has already led to several Nobel prizes. Synthesis of the universal biological energy carrier ATP takes place in the well-characterised soluble domain. The focus of this study is to understand the unknown function of the proton-driven transmembrane motor, which will give fundamental new insights into biological energy conversion and its regulation.

质子转移ATP酶是生物能量转换的核心，生物能量转换是地球上最基本的生物过程之一，其阐明已经获得了多项诺贝尔奖。通用生物能量载体ATP的合成发生在充分表征的可溶性结构域中。本研究的重点是了解质子驱动的跨膜马达的未知功能，这将为生物能量转换及其调控提供新的见解。