Imaging the Machinery of Bacterial Locomotion at Atomic Resolution

以原子分辨率对细菌运动机制进行成像

• 批准号: nhmrc : 1022495
• 负责人: Dr Daniela Stock
• 金额: $ 24.05万
• 依托单位: Victor Chang Cardiac Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/imaging-machinery-bacterial-atomic-resolution/110193
• 关键词: Imaging; Machinery; Bacterial; Locomotion; Atomic

Our aim is to a) understand and b) sabotage the machinery of locomotion in bacteria. The flagellar motor propels bacteria at 100s of revolutions per second through viscous media making this the most powerful motor known to man. Bacteria can sense their environment and make informed decisions to avoid hazards or find food. Understanding how this machinery works in atomic detail is expected to have implications for both the development of new antibacterials and in the area of nano-medicine.

我们的目标是a）了解和B）破坏细菌的运动机制。鞭毛马达以每秒100转的速度推动细菌通过粘性介质，使其成为人类已知的最强大的马达。细菌可以感知环境并做出明智的决定，以避免危险或寻找食物。了解这种机制如何在原子细节中工作，预计将对新抗菌药物的开发和纳米医学领域产生影响。