Structure, function and dynamics of ATP synthases and rotary proton pumps

ATP 合成酶和旋转质子泵的结构、功能和动力学

• 批准号: nhmrc : 1022143
• 负责人: Dr Daniela Stock
• 金额: $ 61.55万
• 依托单位: Victor Chang Cardiac Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structure-function-dynamics-proton-pumps/110167
• 关键词: Structure; function; dynamics; ATP; synthases

ATP synthase is the molecular machinery that converts energy derived from nutrients or photosynthesis into the universal biological fuel source ATP (adenosine triphosphate). This is one of the most fundamental processes of life and is conserved from bacteria to plants to humans. Understanding how ATP synthase and its relatives work in molecular detail is expected to have wide-ranging implications for both medicine (in understanding metabolic disorders) and the design of new antibacterial agents.

ATP合成酶是将营养物质或光合作用产生的能量转化为通用生物燃料来源ATP（三磷酸腺苷）的分子机制。这是生命最基本的过程之一，从细菌到植物再到人类都是如此。了解ATP合酶及其相关酶在分子细节上的工作原理有望对医学（理解代谢紊乱）和新型抗菌剂的设计产生广泛的影响。