Supporting a friend: the role of the molecular scaffold CoREST family in chromatin regulation and neuroprotection

支持朋友：分子支架CoREST家族在染色质调节和神经保护中的作用

• 批准号: nhmrc : 1071250
• 负责人: Dr Lezanne Ooi
• 金额: $ 23.66万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/supporting-friend-role-regulation-neuroprotection/455460
• 关键词: Supporting; friend; role; molecular; scaffold

In diseases such as Alzheimer’s disease, Parkinson’s disease and motor neuron disease, neurons degenerate and die. One contributing factor to neuronal death is inflammation. The aim of this study is to identify mechanisms that protect neurons from death. This project focuses on the role of a family of proteins (CoREST1-3) that function to reverse gene expression changes in inflammation that lead to neurodegeneration.

在阿尔茨海默病、帕金森氏病和运动神经元病等疾病中，神经元退化和死亡。导致神经元死亡的一个因素是炎症。这项研究的目的是确定保护神经元免受死亡的机制。这个项目的重点是一个蛋白质家族(CoREST1-3)的作用，它的功能是逆转导致神经退化的炎症中的基因表达变化。