Inflammation in the Lung: Friend or Foe in Viral Infections?

肺部炎症：病毒感染的朋友还是敌人？

• 批准号: 10681956
• 负责人: TERRY L. SHEPPARD
• 金额: $ 1.5万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10681956
• 关键词: Affect; Aging; Antiviral Response; Area; Automobile Driving; Biological Response Modifiers; Career Mobility; Cell Communication; Cells; Collaborations; Communicable Diseases; Development; Disease; Disease Outcome; Education; Educational workshop; Epidemic; Epithelial Cells; Epithelium; Equilibrium; Event; Fostering; Friends; Future; Growth; Homeostasis; Immune; Immune response; Immunity; Immunologist; Impairment; Industrialization; Infection; Inflammation; Inflammatory; Inflammatory Response; Knowledge; Learning; Lung; Lung infections; Methodology; Modeling; Natural regeneration; Outcome; Participant; Process; Public Health; Research; Research Personnel; Role; Scientist; Severity of illness; Societies; Speed; Stromal Cells; Technology; Therapeutic; Tissues; Translations; Utah; Virus Diseases; Work; adaptive immune response; adaptive immunity; career; cell stroma; clinical implementation; clinical practice; design; immunopathology; improved; innovation; interest; lung development; meetings; multidisciplinary; next generation; novel; novel strategies; pandemic disease; posters; programs; pulmonary function; repaired; respiratory infection virus; response; symposium; synergism; tissue regeneration; tissue repair

ABSTRACT Support is requested for a Keystone Symposia conference entitled Inflammation in the Lung: Friend or Foe in Viral Infections?, organized by Drs. Andreas Wack, Cecilia Johansson and Ivan Zanoni. The conference will be held in Snowbird, Utah from April 23 - 26, 2023. Recent and preceding pandemics and epidemics have dramatically shown the capacity of respiratory virus infections to impact public health and bring society to a standstill. Inflammation takes center stage as it is an important part of the anti-viral response and also sets up subsequent adaptive immune responses and repair. Unfortunately, inflammation also potentially increases tissue damage and impairs or delays tissue regeneration. This conference was designed for attendees to understand better how inflammation enhances or impedes tissue repair and regeneration, as well as how to identify immune mediators that tip the balance between immunopathology and protection and to understand underlying mechanisms. Additionally, this program will include sessions that will discuss the role of innate immune cells in driving the inflammatory response and initiate adaptive immunity. The program will also investigate how the crosstalk between immune and nonimmune cells in the lung affects disease outcomes, and finally, it will highlight new avenues and novel targets for treatment of viral infections. Bringing together experts in the host response to viral infections with scientists working on lung development, repair and regeneration will generate synergies that are not normally achieved in single specialized meetings. Finally, this conference will be held with another Keystone Symposia Conference, “From First Breath: Lung Development, Infection, Repair and Aging.” This pairing will allow participants to bridge the gap between classical antiviral responses carried out by innate and adaptive immune cells, and the involvement of other lung cells such as epithelia and stroma cells, and to deepen the understanding on how these cells interact. This cross-disciplinary interaction will help foster collaborations and develop new angles of treatment of diseases caused by lung infections.

摘要 请求支持一个题为肺部炎症：朋友还是敌人的Keystone研讨会 病毒感染？由安德烈亚斯·瓦克博士、塞西莉亚·约翰逊博士和伊万·扎诺尼博士组织。会议将于 将于2023年4月23日至26日在犹他州雪鸟举行。 最近和之前的大流行和流行病戏剧性地显示了呼吸道病毒的能力 感染会影响公众健康并使社会陷入停滞。炎症占据了中心舞台，因为它是一种 是抗病毒反应的重要组成部分，也是建立后续适应性免疫反应和修复的重要部分。 不幸的是，炎症也可能增加组织损伤，损害或延迟组织 再生。这次会议的目的是让与会者更好地了解炎症是如何增强的。 或阻碍组织修复和再生，以及如何识别打破平衡的免疫介质 免疫病理学和保护之间的关系以及了解潜在的机制。此外，这一点 计划将包括讨论先天免疫细胞在推动炎症反应中的作用的会议 作出反应并启动适应性免疫。该计划还将调查如何免疫之间的串扰 肺中的非免疫细胞影响疾病的结局，最后，它将突出新的途径和新的 病毒感染的治疗目标。将宿主应对病毒感染的专家聚集在一起 致力于肺发育、修复和再生的科学家将产生通常不会产生的协同效应 在单一的专门会议中取得成果。最后，本次会议将与另一场Keystone研讨会一起举行 会议，“从第一次呼吸：肺的发育、感染、修复和衰老。”这一配对将允许 参与者弥合先天免疫和获得性免疫执行的经典抗病毒反应之间的差距 细胞，以及其他肺细胞，如上皮和间质细胞的参与，并加深 了解这些细胞是如何相互作用的。这种跨学科互动将有助于促进协作和 开拓肺部感染所致疾病治疗的新视角。