Synchrotron X-ray assessment of airway surface physiology for cystic fibrosis

我们寻求治愈或长期治疗囊性纤维化中的致命呼吸道疾病。疾病是由浅而脱水的呼吸道表面液体(ASL)引起的，允许细菌感染肺部。我们可以将纠正基因引入老鼠的呼吸道，在那里它可以有效超过一年，但没有快速、准确和非侵入性的测量来测试治疗是否成功。我们将开发使用同步加速器光直接测量活体小鼠呼吸道ASL深度变化的方法。

We seek a cure or long-lasting therapy for the fatal airway disease in cystic fibrosis. Disease is caused by a shallow and dehydrated airway surface liquid (ASL), allowing bacteria to infect the lung. We can introduce a corrective gene into mouse airways where it can be effective for over 1 yr, but no fast, accurate and non-invasive measurement exists to test if treatments are successful. We will develop methods using synchrotron light to directly measure ASL depth changes in live mouse airways.