Targeting an ion pump in the malaria parasite with multiple compound classes

用多种化合物类靶向疟疾寄生虫中的离子泵

• 批准号: nhmrc : 1042272
• 负责人: Prof Kiaran Kirk
• 金额: $ 25.65万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-an-ion-compound-classes/111450
• 关键词: Targeting; ion; pump; malaria; parasite

Large-scale antimalarial drug screening projects have identified three different classes of compound that kill the malaria parasite at extremely low doses and which hold real promise as next-generation antimalarials. Genetic evidence, as well as preliminary data from our own lab, has led us to the hypothesis that all three compound classes exert their antimalarial effect by blocking a molecular ion pump on the parasite surface. The aim of this study is to test this.

大规模的抗疟药物筛选项目已经确定了三种不同类别的化合物，它们可以以极低的剂量杀死疟疾寄生虫，并真实的成为下一代抗疟药物。遗传学证据，以及我们自己实验室的初步数据，使我们假设这三种化合物都是通过阻断寄生虫表面的分子离子泵来发挥抗疟作用的。本研究的目的就是验证这一点。