Expression and characterisation of nutrient transporters from the intracellular malaria parasite, Plasmodium falciparum

细胞内疟原虫恶性疟原虫营养转运蛋白的表达和特征

• 批准号: DP0344425
• 负责人: Prof Kiaran Kirk
• 金额: $ 12.08万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0344425
• 关键词: Expression; characterisation; nutrient; transporters; intracellular

The malaria parasite invades the red blood cells of its host and this provides it with a safe haven in which to grow and replicate. Within the red blood cell, the parasite takes up nutrients and excretes metabolic wastes via specialised membrane transport proteins which are, as yet, very poorly understood. The sequencing of the malaria parasite genome has enabled us to identify candidates for a wide variety of these proteins. The aim of this project is to establish systems in which the functional properties of these transporter proteins may be characterised in detail.

疟疾寄生虫侵入其宿主的红细胞，这为它提供了一个生长和复制的安全避风港。在红细胞内，寄生虫通过特殊的膜运输蛋白吸收营养并排泄代谢废物，目前人们对此还知之甚少。对疟疾寄生虫基因组的测序使我们能够确定这些蛋白质的各种候选者。该项目的目的是建立可以详细描述这些转运蛋白的功能特性的系统。